Nature's Most Powerful Pain Relievers

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Nature has safe nontoxic answers to the crisis of over-reliance and addiction to pain medications with their known harmful effects

Pain is increasingly a part of everyday life for many people. The use of pain medications, including over the counter and prescription non-steroidal anti-inflammatory drugs (NSAIDs) -- ibuprofen, aspirin, naproxen and diclofenac -- and opioids -- legal ones such as morphine, codeine, oxycodone, fentanyl and methadone or illegal narcotics such as heroin -- is escalating to epic proportions. 

More than 96% of all those over the age of 65 have used an NSAID for pain control within the last two weeks.[i] NSAIDs are known to have serious side effects such as gastrointestinal bleeding and ulcers as well as kidney failure and higher cardiovascular risks for strokes and heart attacks.[ii] In England, NSAIDs were associated with 30% of all hospital admissions for preventable adverse drug reactions.[iii]

In 2018, the World Health Organization reported 58 million people worldwide used opioids and overdoses resulted in 350,000 deaths.[iv] According to the U.S. Centers for Disease Control and Prevention, nearly 450,000 people died from overdoses involving an opioid, including prescription and illicit opioids, to manage their pain from 1999 to 2019 in the U.S. alone.[v]

Nature provides many powerful nondrug pain relievers that are effective alternatives to commonly used pain medicines without the detrimental side effects. The four natural options that follow are most helpful as adjunct treatment to reduce the dose and frequency of NSAID and opioid drug use.

1. Curcumin

Curcumin, the major component in turmeric, has anti-inflammatory properties that make it an ideal pain reliever.[vi]

In fact, 367 primary knee osteoarthritis patients with a pain score of five or higher received either ibuprofen at a dose of 1,200 milligrams (mg) per day or Curcuma domestica (turmeric) extract (1,500 mg per day) for four weeks showing the tumeric group had comparable pain relief benefits to the ibuprofen group but with fewer gastrointestinal adverse events.[vii]

Similarly, in a meta-analysis of eight trials, researchers showed extracts from the Zingiberaceae family, including turmeric and ginger, were as effective in reducing chronic pain as NSAIDs but without the renal risks.[viii]

The effective action of curcumin on neuropathic pain was shown in a mouse model using curcumin doses of 5, 15 or 45 mg per kg, twice per day for three weeks, and as doses increased so did their power to effectively alleviate pain caused by mechanical and thermal stimuli in mice.[ix]

In a formalin-induced orofacial pain model in rats, the analgesic response of curcumin was observed at doses of 25, 50, 100, 200, 400 and 600 mg per kg administered 15 minutes prior to formalin injection; in the group receiving a low dose of diclofenac (0.2 mg per kg) with curcumin at 25 mg per kg, curcumin increased the power of the lower dose of the NSAID diclofenac.[x]

In an acetic acid pain-induced model of rats, curcumin at 20 and 40 mg per kg produced the same pain reducing effect as the opioid morphine at 1 mg per kg.[xi]

2. Cannabidiol (CBD) Oil

In a review of medical cannabis as a therapy for symptom management in palliative care, there is sufficient evidence to determine the effectiveness and safety of cannabinoids for chronic pain.[xii] Osteoarthritis pain is one of the most common types of pain and scientific evidence shows that cannabinoids are effective pain relievers to fight inflammatory, nociceptive and neuropathic pain modalities found in joint pain.[xiii]

In 11 trials of 1,219 patients with neuropathic pain, those who took cannabinoids versus conventional treatments of pharmaceuticals and/or physical therapy had small reductions in pain scores, improvements in quality of life and increased sleep with no major adverse effects. However, larger studies are needed to clarify the most effective dosage, duration and quality of cannabinoids for pain relief.[xiv]

The 16-week trial results of treatment with the cannabinoid dronabinol show it is a safe and effective long-term treatment option that reduced neuropathic pain intensity in a study of 240 multiple sclerosis patients.[xv]

Cannabinoids also proved to be low-cost and well-tolerated therapies to reduce pain and fatigue symptoms and increase the quality of life of 17 women with fibromyalgia.[xvi] In three case studies of patients with epidermolysis bullosa, a genetic blistering disorder characterized by intense pain, cannabinoids improved pain scores, reduced itchy skin and decreased intake of opioids, the most common treatment for this type of pain.[xvii]

Increasing evidence shows that cannabinoids act synergistically with opioids and as opioid sparing agents, allowing lower doses and fewer side effects when compared to chronic opioid therapy for severe pain.[xviii]

3. Aromatherapy

Aromatherapy, using essential oils such as lavender, rose, bergamot and frankincense, is an effective and safe natural alternative for alleviating pain. Administration of opioids and NSAIDs has been the mainstay for postoperative pain control but patients often have serious adverse effects from these drugs, while essential oils have few if any serious side effects.

For example, in an aromatherapy trial, 82% of the patients in the placebo group required NSAIDs for postoperative pain while only 46% did in the lavender group and the lavender group required significantly less morphine, 2.38 mg versus 4.26 mg, postoperatively than the placebo group.[xix]

In a clinical trial of 64 children of 3 to 6 years of age having surgery, the group that was given inhalation aromatherapy with rose oil showed significantly lower pain scores than the placebo group given almond oil, demonstrating the efficacy of aromatherapy for postoperative pain in children without any significant side effects.[xx]

Similarly, in a study of 50 patients with second- and third-degree burns, those given inhalation aromatherapy with rose oil had decreased pain intensity and severity caused from dressing the burns compared to those in the control group.[xxi]

In a study of 58 hospice cancer patients, those who were treated to an aroma hand massage with lavender, bergamot and frankincense oils for five minutes a day for a week had less pain compared to the placebo group given almond oil massages.[xxii]

To study the effects of aromatherapy on 12 healthy volunteers, those taking frankincense at 125 mg or two capsules of the Boswellia serrata supplement significantly increased their pain threshold and pain tolerance force and time compared to the placebo group.[xxiii]

Examining the use of aromatherapy for pain management in a meta-analysis of 12 studies, researchers found evidence of reduced pain overall and the most consistent and effective results in treating postoperative, obstetrical and gynecological pain.[xxiv]

4. Palmitoylethanolamide

Palmitoylethanolamide (PEA), a nutraceutical supplement that is also available in PEA-rich foods such as soy lecithin, soybeans, egg yolks, peanuts and alfalfa, has been used successfully for pain management.[xxv] In a meta-analysis of 10 studies from 786 patients, those who received the PEA supplement experienced significantly lower acute or chronic pain compared to placebo groups.[xxvi]

The use of PEA as an add-on treatment to the opioid drug tapentadol in a study of 55 patients with chronic lower back pain resulted in significantly reduced pain intensity, less disability and lower opioid dosage over time.[xxvii]

In a study of 54 patients with irritable bowel syndrome and 12 healthy controls, patients taking 200 mg of PEA over a 12-week period showed markedly improved abdominal pain severity compared to the control group.[xxviii]

Comparing the effectiveness of PEA against the NSAID ibuprofen in a trial of 24 patients with temporomandibular joint osteoarthritis, those taking PEA for pain relief had significantly less pain and more mouth movement after two weeks compared to the ibuprofen group.[xxix]

For both sciatic and carpal tunnel syndrome pain, PEA demonstrated efficacy and safety as an anti-inflammatory and analgesic treatment in over 30 clinical trials and more than 6,000 patients making it an excellent alternative to opioids in treating nerve-related pain without harmful side effects.[xxx]

Pain Relief From Nature

Nature has provided us with many options that are safe and effective in managing pain. While pharmaceuticals may have a place in severe pain relief in small doses and short treatment windows, it is important to know what alternative treatments are available to reduce drug overuse, addiction and harmful side effects.

To learn more, see's databases on Pain, Analgesics, Curcumin, Cannabidiol, Aromatherapy and Palmitoylethanolamide (PEA).


[i] Pilotto A, Franceschi M, Leandro G, Di Mario F; Geriatric Gastroenterology Study Group (Societè Italiana Gerontologie Geriatria). NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies. Drugs Aging. 2003;20(9):701-10. doi: 10.2165/00002512-200320090-00006. PMID: 12831293.

[ii] Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. Aging Dis. 2018 Feb 1;9(1):143-150. doi: 10.14336/AD.2017.0306. PMID: 29392089; PMCID: PMC5772852.

[iii] Davis A, Robson J. The dangers of NSAIDs: look both ways. Br J Gen Pract. 2016 Apr;66(645):172-3. doi: 10.3399/bjgp16X684433. PMID: 27033477; PMCID: PMC4809680.

[iv] World Health Organization International, News Room, Fact Sheets, Opioid Overdose.

[v] Wide-ranging online data for epidemiologic research (WONDER). Atlanta, GA: CDC, National Center for Health Statistics; 2020.

[vi] Wing-Hin Lee, Ching-Yee Loo , Mary Bebaw Lee W.H., Frederick Luk , Rebecca S Mason and Ramin Rohanizadeh (2013). Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century. Current Neuropharmacology, 11(4): 338-378.

[vii] Vilai Kuptniratsaikul, Piyapat Dajpratham, Wirat Taechaarpornkul, Montana Buntragulpoontawee, Pranee Lukkanapichonchut, Chirawan Chootip, Jittima Saengsuwan, Kesthamrong Tantayakom, Supphalak Laongpech. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 ;9:451-8. Epub 2014 Mar 20. PMID: 24672232

[viii] Shaheen E Lakhan, Christopher T Ford, Deborah Tepper. Zingiberaceae extracts for pain: a systematic review and meta-analysis. Nutr J. 2015 ;14:50. Epub 2015 May 14. PMID: 25972154

[ix] Xin Zhao, Ying Xu, Qing Zhao, Chang-Rui Chen, Ai-Ming Liu, Zhi-Li Huang. Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: Descending monoamine system and opioid receptors are differentially involved. Neuropharmacology. 2012 Feb ;62(2):843-54. Epub 2011 Sep 19. PMID: 21945716

[x] Niti Mittal, Rupa Joshi, Debasish Hota, Amitava Chakrabarti. Evaluation of antihyperalgesic effect of curcumin on formalin-induced orofacial pain in rat. Phytother Res. 2009 Apr;23(4):507-12. PMID: 19051211

[xi] Hossein Tajik, Esmaeal Tamaddonfard, Nasrin Hamzeh-Gooshchi. The effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats. Pak J Biol Sci. 2008 Jan 15;11(2):312-4. PMID: 18817212

[xii] Cari Levy, Emily Galenbeck, Kate Magid. Cannabis for Symptom Management in Older Adults. Med Clin North Am. 2020 May ;104(3):471-489. PMID: 32312410

[xiii] Melissa O'Brien, Jason J McDougall. Cannabis and joints: scientific evidence for the alleviation of osteoarthritis pain by cannabinoids. Curr Opin Pharmacol. 2018 Apr 7 ;40:104-109. Epub 2018 Apr 7. PMID: 29635215

[xiv] Meng H, Johnston B, Englesakis M, Moulin DE, Bhatia A. Selective Cannabinoids for Chronic Neuropathic Pain: A Systematic Review and Meta-analysis. Anesth Analg. 2017 Nov;125(5):1638-1652. doi: 10.1213/ANE.0000000000002110. PMID: 28537982.

[xv] Sebastian Schimrigk, Martin Marziniak, Christine Neubauer, Eva Maria Kugler, Gudrun Werner, Dimitri Abramov-Sommariva. Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients. Eur Neurol. 2017 Oct 26 ;78(5-6):320-329. Epub 2017 Oct 26. PMID: 29073592

[xvi] Carolina Chaves, Paulo Cesar T Bittencourt, Andreia Pelegrini. Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Pain Med. 2020 Oct 1 ;21(10):2212-2218. PMID: 33118602

[xvii] N H B Schräder, J C Duipmans, B Molenbuur, A Wolff, M F Jonkman. Combined THC and CBD to treat pain in epidermolysis bullosa: a report of three cases. Br J Dermatol. 2018 Oct 22. Epub 2018 Oct 22. PMID: 30347109

[xviii] Jaseena Elikkottil, Jaseena Elikottil, Pankaj Gupta, Kalpna Gupta. The analgesic potential of cannabinoids. J Opioid Manag. 2009 Nov-Dec;5(6):341-57. PMID: 20073408

[xix] Jung T Kim, Christine J Ren, George A Fielding, Abhishek Pitti, Takeo Kasumi, Michael Wajda, Allen Lebovits, Alex Bekker. Treatment with lavender aromatherapy in the post-anesthesia care unit reduces opioid requirements of morbidly obese patients undergoing laparoscopic adjustable gastric banding. Obes Surg. 2007 Jul;17(7):920-5. PMID: 17894152

[xx] Maryam Marofi, Motahareh Sirousfard, Mahin Moeini, Alireza Ghanadi. Evaluation of the effect of aromatherapy with Rosa damascena Mill. on postoperative pain intensity in hospitalized children in selected hospitals affiliated to Isfahan University of Medical Sciences in 2013: A randomized clinical trial. Iran J Nurs Midwifery Res. 2015 Mar-Apr;20(2):247-54. PMID: 25878704

[xxi] Ali Bikmoradi, Mehdi Harorani, Ghodratollah Roshanaei, Shirin Moradkhani, Golam Hossein Falahinia. The effect of inhalation aromatherapy with damask rose (Rosa damascena) essence on the pain intensity after dressing in patients with burns: A clinical randomized trial. Iran J Nurs Midwifery Res. 2016 May-Jun;21(3):247-54. PMID: 27186201

[xxii] So Young Chang. Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer. Taehan Kanho Hakhoe Chi. 2008 Aug ;38(4):493-502. PMID: 18753801

[xxiii] K Prabhavathi, U Shobha Jagdish Chandra, Radhika Soanker, P Usha Rani. A randomized, double blind, placebo controlled, cross over study to evaluate the analgesic activity of Boswellia serrata in healthy volunteers using mechanical pain model. Indian J Pharmacol. 2014 Sep-Oct;46(5):475-9. PMID: 25298573

[xxiv] Shaheen E Lakhan, Heather Sheafer, Deborah Tepper. The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis. Pain Res Treat. 2016 ;2016:8158693. Epub 2016 Dec 14. PMID: 28070420

[xxv] Petrosino S, Di Marzo V. The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations. Br J Pharmacol. 2017 Jun;174(11):1349-1365. doi: 10.1111/bph.13580. Epub 2016 Sep 29. PMID: 27539936; PMCID: PMC5429331.

[xxvi] Paladini A, Fusco M, Cenacchi T, Schievano C, Piroli A, Varrassi G. Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis. Pain Physician. 2016 Feb;19(2):11-24. PMID: 26815246

[xxvii] Maria Beatrice Passavanti, Marco Fiore, Pasquale Sansone, Caterina Aurilio, Vincenzo Pota, Manlio Barbarisi, Daniela Fierro, Maria Caterina Pace. The beneficial use of ultramicronized palmitoylethanolamide as add-on therapy to Tapentadol in the treatment of low back pain: a pilot study comparing prospective and retrospective observational arms. BMC Anesthesiol. 2017 Dec 19 ;17(1):171. Epub 2017 Dec 19. PMID: 29258432

[xxviii] C Cremon, V Stanghellini, M R Barbaro, R F Cogliandro, L Bellacosa, J Santos, M Vicario, M Pigrau, C Alonso Cotoner, B Lobo, F Azpiroz, S Bruley des Varannes, M Neunlist, D DeFilippis, T Iuvone, S Petrosino, V Di Marzo, G Barbara. Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome. Aliment Pharmacol Ther. 2017 04 ;45(7):909-922. Epub 2017 Feb 6. PMID: 28164346

[xxix] Ida Marini, Maria Lavinia Bartolucci, Francesco Bortolotti, Maria Rosaria Gatto, Giulio Alessandri Bonetti. Palmitoylethanolamide versus a nonsteroidal anti-inflammatory drug in the treatment of temporomandibular joint inflammatory pain. J Orofac Pain. 2012 ;26(2):99-104. PMID: 22558609

[xxx] Jan M Keppel Hesselink, David J Kopsky. Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome. J Pain Res. 2015 ;8:729-34. Epub 2015 Oct 23. PMID: 26604814

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