Can Clay Help Adsorb Harmful Aflatoxins in the Body? Texas Trial Provides Clues

Views 3753

A silent threat contaminates foods across the globe, but a common clay shows promise for intervention

Researchers conducted a study in Texas to evaluate if taking a refined calcium montmorillonite clay called ACCS100 could help lower exposure to aflatoxins,[1] toxic chemicals produced by Aspergillus mold species that contaminate many foods globally.

Aflatoxin exposure through contaminated food[2] is unfortunately extremely common across the developing world.[3] However, due to the unpredictable nature of Aspergillus fungal growth, even countries with modern agricultural practices like the United States are susceptible to sporadic contamination events, especially as the climate warms.[4][5] Corn,[6] peanuts,[7] tree nuts,[6] spices,[8] rice,[9] wheat,[10] cottonseed,[11] milk,[12] and other grains/legumes[6] are among the most commonly contaminated food products. Chronic dietary exposure[13] to these aflatoxins (especially Aflatoxin B1) is a major risk factor for developing liver disease and hepatocellular carcinoma (HCC), a form of liver cancer.[14]

This randomized clinical trial, conducted from 2012-2014, enrolled 234 healthy adult volunteers from Texas' Bexar and Medina Counties, areas with elevated liver cancer rates. Participants were randomly split into 3 groups and given either a placebo, 1.5 grams per day of ACCS100 (low dose), or 3 grams per day (high dose), taken orally in capsule form over 3 months.

Researchers analyzed changes in the aflatoxin B1-lysine serum protein adduct (AFB1-lysine), a validated biomarker of internal aflatoxin exposure,[15] in blood samples taken at baseline, 1 month, 3 months and 1 month post-treatment.

Both ACCS100 doses appeared extremely safe based on self-reported symptoms and standard blood tests. The low dose ACCS100 group saw AFB1-lysine levels drop significantly, around 35% compared to placebo after 1 and 3 months of treatment.[16]

While further trials are warranted, this initial Texas study demonstrates refined calcium montmorillonite clays could be a promising interventional strategy to reduce aflatoxin exposures from contaminated foods.


References

[1] https://pubmed.ncbi.nlm.nih.gov/8298870/

[2] https://www.sciencedirect.com/science/article/pii/B9780128018291000187

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139241/  

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093071/

[5] https://www.sciencedirect.com/science/article/pii/S0956713507003249

[6] https://www.ncbi.nlm.nih.gov/books/NBK304113/

[7] https://onlinelibrary.wiley.com/doi/10.1002/jsfa.2740370306

[8] https://www.tandfonline.com/doi/abs/10.1080/19440049.2013.851739

[9] https://aem.asm.org/content/76/20/6895

[10] https://www.sciencedirect.com/science/article/pii/S0956713506002973  

[11] https://pubag.nal.usda.gov/catalog/42856

[12] https://www.karger.com/Article/FullText/488837

[13] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412222/

[14] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632998/  

[15] https://pubmed.ncbi.nlm.nih.gov/8722216/

[16] https://www.tandfonline.com/doi/full/10.1080/19440049.2016.1198498

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.