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Article Publish Status: FREE
Abstract Title:

Weight reduction improves immune system and inflammatory cytokines in obese asthmatic patients.

Abstract Source:

Afr Health Sci. 2020 Jun ;20(2):897-902. PMID: 33163057

Abstract Author(s):

Fadwah M Al-Sharif, Shehab M Abd El-Kader, Ziyad A Neamatallah, Afnan M AlKhateeb

Article Affiliation:

Fadwah M Al-Sharif

Abstract:

Background: Activation of immunological and systemic inflammation markers are common in obesity and asthma.

Objective: The target of this study was to assess impact of weight reduction on immunological and systemic inflammation markers in obese asthma patients.

Material and methods: Eighty asthmatic patients of both sex; their age and body mass index (BMI) mean were 38.72± 7.14 year and 32.65 ± 3.18 Kg/m2 respectively. Exclusion criteria included smokers, infections, vaccinations, cancer, surgery, immune system disorders and medications that may influence immune system function as anti-inflammatory medications, analgesics and anti-depressant. All subjects were randomly enrolled in weight reduction group (group A) or control group (group B).

Results: The main findings in the present study indicated that weight reducing program in group (A) was associated with significant reduction in the mean values of IL6, TNF-α, and IL8 in addition to significant increase in the mean values of CD4 and CD8 cell count . However, findings of group (B) showed no significant changes. Moreover, Comparison between both groups at the end of the study revealed significant differences.

Conclusion: Weight reduction improved immunological and systemic inflammation markers in obese asthma patients.

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