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Article Publish Status: FREE
Abstract Title:

Ursolic Acid Protects Sodium Dodecyl Sulfate-InducedUlcerative Colitis Model by Inhibiting the JNK Signaling.

Abstract Source:

Antioxidants (Basel). 2022 Feb 21 ;11(2). Epub 2022 Feb 21. PMID: 35204308

Abstract Author(s):

Tian Wei, Lei Wu, Xiaowen Ji, Yan Gao, Guiran Xiao

Article Affiliation:

Tian Wei

Abstract:

Ursolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables, which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic chemicals. However, the underlying mechanism has not been well clarified in vivo. Here, using aUC model induced by sodium dodecyl sulfate (SDS), we investigated the defensive effect of UA on intestinal damage. The results showed that UA could significantly protectfrom the damage caused by SDS exposure. Further, UA alleviated the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by SDS and upregulated the activities of total superoxide dismutase (T-SOD) and catalase (CAT). Moreover, the proliferation and differentiation of intestine stem cells (ISCs) as well as the excessive activation of the c-Jun N-terminal kinase (JNK)-dependent JAK/STAT signaling pathway induced by SDS were restored by UA. In conclusion, UA prevents intestine injury from toxic compounds by reducing the JNK/JAK/STAT signaling pathway. UA may provide a theoretical basis for functional food or natural medicine development.

Study Type : Animal Study

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