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Abstract Title:

Treatment efficacy of,,, andextracts in-induced rabbit dermatitis model.

Abstract Source:

Vet World. 2022 Jan ;15(1):188-197. Epub 2021 Jan 29. PMID: 35369604

Abstract Author(s):

Charinya So-In, Nuchsupha Sunthamala

Article Affiliation:

Charinya So-In

Abstract:

Background and Aim: Dermatitis is a soft-tissue infection caused by. The recurrence of inflammatory skin is linked to clinical manifestations. Anti-inflammatory cytokines, which are essential for tissue damage, are released by bacteria through skin tissues. Oxidative stress causes inflammatory cells to necrotize and reduces their antioxidant profile, resulting in toxic damage to surrounding tissues. Although studies on the antibacterial effects ofLindl.,L.,L., and(Burm.). Bacterial infection ofhave been conducted, most of these studies have beenand were not related to the rabbit model. In addition, anti-inflammatory and antioxidant studies need to be evaluated. Thus, this study aims to compare the antibacterial, anti-inflammatory, and antioxidant properties of four local herbs with a standard antibiotic in-induced rabbit dermatitis model.

Materials and Methods: The skin of New Zealand white rabbits were artificially wounded using a sterile blade and then infected with. The rabbits were divided into seven groups, each with three rabbits (Total 21 rabbits): The first group was the no infection group (no infection and no treatment with scarification), the second group was the no treatment group (infection of the wound but no treatment), and the other five treated groups were, and bacitracin cream, all of which involved wound infection and treatments. The treatment lasted for 7 days. The antibacterial, anti-inflammatory, and antioxidant properties after treatment were measured.

Results: The efficacy of,,, andwas similar to that of an antioxidant and free radical scavenging property. The bacterial infection process gradually reduced the activities of antioxidant systems (i.e., enzymatic levels and gene expressions) and total glutathione. However, the activities of the antioxidant system were steadily increased when treated with herbal extracts. During bacterial invasion of the skin, the concentration of thiobarbituric acid reactive molecules, the level of lipid peroxidation, and the expression of anti-inflammatory cytokine genes were increased. All these were decreased when herbal extracts were used to treat the lesion.

Conclusion: It can be concluded that, and. paniculate extract have antibacterial, anti-inflammatory, and antioxidant properties and are effective antibacterial agents.is the most effective herbal extract for antidermatitis and has the potential to be used as an alternative topical treatment.

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