Article Publish Status: FREE
Abstract Title:

Perfluorooctanoic acid induces human Ishikawa endometrial cancer cell migration and invasion through activation of ERK/mTOR signaling.

Abstract Source:

Oncotarget. 2016 Aug 29. Epub 2016 Aug 29. PMID: 27589685

Abstract Author(s):

Zhinan Ma, Xiaoqiu Liu, Fujun Li, Yixong Wang, Yang Xu, Mei Zhang, Xiaoqian Zhang, Xiaoyan Ying, Xuesen Zhang

Article Affiliation:

Zhinan Ma


Perfluorooctanoic acid (PFOA) is a common environmental pollutant that has been associated with various diseases, including cancer. We explored the molecular mechanisms underlying PFOA-induced endometrial cancer cell invasion and migration. PFOA treatment enhanced migration and invasion by human Ishikawa endometrial cancer cells, which correlated with decreased E-cadherin expression, a marker of epithelial-mesenchymal transition. PFOA also induced activation of ERK1/2/mTOR signaling. Treatment with rapamycin, an mTOR inhibitor, antagonized the effects of PFOA and reversed the effects of PFOA activation in a xenograft mouse model of endometrial cancer. Consistent with these results, pre-treatment with rapamycin abolished PFOA-induced down-regulation of E-cadherin expression. These results indicate that PFOA is a carcinogen that promotes endometrial cancer cell migration and invasion through activation of ERK/mTOR signaling.

Study Type : Animal Study, In Vitro Study
Additional Links
Adverse Pharmacological Actions : Carcinogen : CK(62) : AC(13)

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