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Abstract Title:

Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials.

Abstract Source:

Front Public Health. 2022 ;10:903547. Epub 2022 Aug 1. PMID: 35979473

Abstract Author(s):

Fei Xie, Tongmin Huang, Dandi Lou, Rongrong Fu, Chaoxiong Ni, Jiaze Hong, Lingyan Ruan

Article Affiliation:

Fei Xie

Abstract:

Background: There have been several controversies about the correlation between vitamin D and depression. This study aimed to investigate the relationship between vitamin D supplementation and the incidence and prognosis of depression and to analyze the latent effects of subgroups including population and supplement strategy.

Methods: A systematic search for articles before July 2021 in databases (PubMed, EMBASE, Web of Science, and the Cochrane Library) was conducted to investigate the effect of vitamin D supplementation on the incidence and prognosis of depression.

Results: This meta-analysis included 29 studies with 4,504 participants, indicating that the use of vitamin D was beneficial to a decline in the incidence of depression (SMD: -0.23) and improvement of depression treatment (SMD: -0.92). Subgroup analysis revealed that people with low vitamin D levels (<50 nmol/L) and females could notably benefit from vitamin D in both prevention and treatment of depression. The effects of vitamin D with a daily supplementary dose of>2,800 IU and intervention duration of≥8 weeks were considered significant in both prevention and treatment analyses. Intervention duration ≤8 weeks was recognized as effective in the treatment group.

Conclusion: Our results demonstrate that vitamin D has a beneficial impact on both the incidence and the prognosis of depression. Whether suffering from depression or not, individuals with low vitamin D levels, dose>2,800 IU, intervention duration≥8 weeks, and all females are most likely to benefit from vitamin D supplementation.

Study Type : Meta Analysis

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