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Article Publish Status: FREE
Abstract Title:

Supplementation withPrevents Damage to Rat Erections in a Model of Erectile Dysfunction Promoted by Hypercaloric Diet-Induced Obesity.

Abstract Source:

Mar Drugs. 2022 Jul 22 ;20(8). Epub 2022 Jul 22. PMID: 35892935

Abstract Author(s):

Iara Leão Luna de Souza, Bárbara Cavalcanti Barros, Elba Dos Santos Ferreira, Fernando Ramos Queiroga, Luiz Henrique César Vasconcelos, Lydiane de Lima Tavares Toscano, Alexandre Sérgio Silva, Patrícia Mirella da Silva, Fabiana de Andrade Cavalcante, Bagnólia Araújo da Silva

Article Affiliation:

Iara Leão Luna de Souza

Abstract:

Erectile dysfunction (ED) is the inability to achieve and/or maintain a penile erection sufficient for sexual satisfaction. Currently, many patients do not respond to the pharmacotherapy. The effects of a supplementation with, were evaluated in a model of ED induced by hypercaloric diet consumption. Wistar rats were divided into groups fed with standard diet (SD) or hypercaloric diet (HD) and supplemented with this alga at doses of 25, 50 or 100 mg/kg. Experimental adiposity parameters and erectile function were analyzed. In SD groups,reduced food intake, final body mass and adiposity index, and increased the total antioxidant capacity (TAC) of adipose tissue. However, no change was observed in erectile function. In the HD group, withoutsupplementation, a decrease in food intake was observed, in addition to an increase of final body mass, weight gain, adipose reserves, and adiposity index. Additionally, reduction in the number and increase in the latency of penile erection and adipose malondialdehyde levels, as well as a reduction in TCA was noted. Furthermore, cavernous contractility was increased, and the relaxing response was decreased. Interestingly, these deleterious effects were prevented by the algae at doses of 25, 50 and/or 100 mg/kg. Therefore, the supplementation withprevents damages associated to a hypercaloric diet consumption and emerges as an adjuvant the prevention of ED.

Study Type : Animal Study

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