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Article Publish Status: FREE
Abstract Title:

Protective Effects of Cinnamaldehyde on the Inflammatory Response, Oxidative Stress, and Apoptosis in Liver of-Challenged Mice.

Abstract Source:

Molecules. 2021 Apr 16 ;26(8). Epub 2021 Apr 16. PMID: 33923441

Abstract Author(s):

Renjie Wang, Senlin Li, Hai Jia, Xuemeng Si, Yan Lei, Jirong Lyu, Zhaolai Dai, Zhenlong Wu

Article Affiliation:

Renjie Wang

Abstract:

infection is associated with gastrointestinal disorder and cellular injury in the liver of both humans and animals. Cinnamaldehyde, the main component of essential oil from cinnamon, has been reported to have anti-inflammatory, anti-oxidative, and anti-apoptotic effects. However, it remains unknown whether cinnamaldehyde can alleviateinfection-induced liver injury in mice. In the present study, we found that cinnamaldehyde attenuated-induced body weight loss, the increase of organ (liver and spleen) indexes, hepatocyte apoptosis, and the mortality rate in mice. Further study showed that cinnamaldehyde significantly alleviated-induced liver injury as shown by activities of alanine transaminase, aspartate transaminase, and myeloperoxidase, as well as malondialdehyde. The increased mRNA level of pro-inflammatory cytokines (,,, and) and chemokines (and) induced bywere significantly abolished by cinnamaldehyde supplementation. These alterations were associated with a regulatory effect of cinnamaldehyde on,, and. 16S rDNA sequence analysis showed thatinfection led to upregulation of the abundances of genera,,,, and, and downregulation of the abundances of genera,, and(unclassified). These alterations were reversed by cinnamaldehyde supplementation. In conclusion, cinnamaldehyde attenuated the inflammatory response, oxidative stress, and apoptosis in the liver of-infected mice. Supplementation of cinnamaldehyde might be a preventive strategy to alleviate liver injury caused byinfection in humans and animals.

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