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Article Publish Status: FREE
Abstract Title:

ameliorates insulin resistance in high- fructose-fed insulin-resistant rats.

Abstract Source:

Iran J Basic Med Sci. 2017 Oct ;20(10):1093-1101. PMID: 29147484

Abstract Author(s):

Hossein Fallah, Hamed Akbari, Moslem Abolhassani, Abbas Mohammadi, Ahmad Gholamhosseinian

Article Affiliation:

Hossein Fallah

Abstract:

OBJECTIVES: This study was aimed to investigate the effect ofextract on insulin sensitivity in high-fructose-fed insulin-resistant rats.

MATERIALS AND METHODS: Experimental rats were randomly divided into two groups: the control group was fed a regular chow diet while other group fed with a high-fructose diet for 8 weeks. After the first six weeks, the animals were treated withextract or pioglitazone for two weeks. Insulin and adiponectin levels were measured by ELISA. Additionally, Insulin resistance was calculated using a Homeostasis Model Assessment of Insulin resistance (HOMA-IR). The plasma free fatty acid (FFA) profile was obtained by gas chromatography. PPARγ and GLUT4 gene expression were assessed by real-time polymerase chain reaction (PCR) and western-blotting.

RESULTS: Comparing thetreated group with the control group, weight gain (=0.009) and levels of insulin (=0.001), blood glucose (<0.0001), and HOMA-IR (<0.0001) were significantly reduced. Additionally, the adiponectin concentration was significantly increased (<0.0001). Among the FFA fractions, the mean concentration of palmitoleic acid and stearic acid in thegroup were significantly higher than the control group (<0.0001 and=0.005, respectively). However, there was no significant difference at the mRNA and protein level of GLUT4 and PPAR-γ between B.treated group and control group.

CONCLUSION: The study findings revealed thatmight be a protective candidate against Type 2 diabetes/insulin resistance through direct insulin-like effect and an increase in adiponectin levels. However, the mechanism ofwas independent of GLUT4 and PPARγ.

Study Type : Animal Study

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