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Abstract Title:

Simultaneous co-detection of wild-type and vaccine strain measles virus using the BD MAX system.

Abstract Source:

Pathology. 2018 Jun ;50(4):450-454. Epub 2018 May 8. PMID: 29752126

Abstract Author(s):

Kiran Thapa, Justin A Ellem, Kerri Basile, Ian Carter, Tom Olma, Sharon C-A Chen, Dominic E Dwyer, Jen Kok

Article Affiliation:

Kiran Thapa

Abstract:

Despite the reported elimination of measles virus in Australia, importation of cases from endemic countries continues to lead to secondary local transmission and outbreaks. Rapid laboratory confirmation of measles is paramount for individual patient management and outbreak responses. Further, it is important to rapidly distinguish infection from wild-type virus or vaccine strains to guide public health responses. We developed a high throughput, TaqMan-based multiplex reverse-transcription-polymerase chain reaction (PCR) assay using the BD MAX platform (Becton Dickinson) that simultaneously detects measles virus and differentiates between wild-type and vaccine strains without the need for sequencing.

Study Type : In Vitro Study

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