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Article Publish Status: FREE
Abstract Title:

 discovery of non-psychoactive scaffolds in Cannabis halting SARS-CoV-2 host entry and replication machinery.

Abstract Source:

Future Virol. 2022 Mar ;0(0). Epub 2022 Apr 4. PMID: 35399958

Abstract Author(s):

Amira R Khattab, Mohamed Teleb

Article Affiliation:

Amira R Khattab

Abstract:

Coronavirus disease still poses a global health threat which advocates continuous research efforts to develop effective therapeutics.We screened out an array of 29 cannabis phytoligands for their viral spike-ACE2 complex and main protease (M) inhibitory actions bymodeling to explore their possible dual viral entry and replication machinery inhibition. Physicochemical and pharmacokinetic parameters (ADMET) formulating drug-likeness were computed.Among the studied phytoligands, cannabigerolic acid, cannabigerol, and its acid methyl etherpossessed the highest binding affinities to SARS-CoV-hACE2 complex essential for viral entry. Canniprene, cannabigerolic methyl etherand cannabichromenewere the most promising Minhibitors.These non-psychoactive cannabinoids could represent plausible therapeutics with added-prophylactic value as they halt both viral entry and replication machinery.

Study Type : In Vitro Study

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Sayer Ji
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