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Article Publish Status: FREE
Abstract Title:

Survival of Laryngeal Cancer Patients Depending on Zinc Serum Level and Oxidative Stress Genotypes.

Abstract Source:

Biomolecules. 2021 06 10 ;11(6). Epub 2021 Jun 10. PMID: 34200699

Abstract Author(s):

Jakub Lubiński, Ewa Jaworowska, Róża Derkacz, Wojciech Marciniak, Katarzyna Białkowska, Piotr Baszuk, Rodney J Scott, Jan A Lubiński

Article Affiliation:

Jakub Lubiński

Abstract:

Stress contributes to various aspects of malignancy and could influence survival in laryngeal cancer patients. Among antioxidant mechanisms, zinc and the antioxidant enzymes superoxide dismutase 2, catalase and glutathione peroxidase 1 play a major role. The aim of this study was a prospective evaluation of the survival of patients with laryngeal cancer in relation to serum levels of zinc in combination with functional genotype differences of three key antioxidant enzymes. The study group consisted of 300 patients treated surgically for laryngeal cancer. Serum zinc levels and common polymorphisms in,andwere analyzed. The risk of death in patients with the lowest zinc levels was increased in comparison with patients with the highest levels. Polymorphisms of antioxidant genes by themselves were not correlated with survival, however, serum zinc level impact on survival was stronger forandvariants.polymorphisms did not correlate with zinc levels regarding survival. In conclusion, serum zinc concentration appears to be an important prognostic factor for survival of patients diagnosed with laryngeal cancer. When higher zinc levels were correlated with polymorphisms inanda further increase in survival was observed.

Study Type : Human Study

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