Salvia miltiorrhiza-asarum ointment combined with Chinese medical massage alleviates symptoms of osteoarthritis. - GreenMedInfo Summary

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Abstract Title:

Salvia miltiorrhiza-asarum ointment combined with Chinese medical massage alleviates symptoms of osteoarthritis in a rat model through the Notch1/ matrix metalloproteinase-13 signaling pathway.

Abstract Source:

J Tradit Chin Med. 2021 Aug ;41(4):600-607. PMID: 34392653

Abstract Author(s):

Qing-Zhong Lai, Xian-Jie Zhang, Mei-Lan Chen, Zhi-Cun Han

Article Affiliation:

Qing-Zhong Lai

Abstract:

OBJECTIVE: This study investigated the effect of salvia miltiorrhiza-asarum ointment (SMAO) plus Chinese medical massage on knee osteoarthritis in a rat model.

METHODS: Hulth's method was used to establish a Sprague-Dawley rat model of knee osteoarthritis (OA). The levels of matrix metalloproteinase-13 (MMP-13), collagen-II, aggrecan, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and IL-6 were measured by enzyme-linked immunosorbent assays. The joint space was assessed by a Perlove X-ray system. Histopathology was examined by hematoxylin-eosin and Safranin O staining. The mRNA and protein expression levels of Notch1, MMP-13, collagen-II, and aggrecan were measured by quantitative reverse transcription-polymerase chain reaction and Western blotting, respectively.

RESULTS: SMAO plus Chinese medical massage significantly decreased the levels of MMP-13, IL-1β, TNF-α, and IL-6, and increased serum collagen-II and aggrecan levels. Pathological injury of the knee joint was improved by SMAO treatment. mRNA and protein expression of Notch1 and MMP-13 was remarkably downregulated, but collagen-II and aggrecan levels were significantly upregulated in cartilage tissues.

CONCLUSION: SMAO combined with Chinese medical massage effectively relieves OA symptoms, which may involve inhibiting inflammation through the Notch1/MMP-13 signaling pathway.

Article Published Date : Jul 31, 2021

Study Type : Animal Study

Additional Links

Substances : Salvia miltiorrhiza : CK(417) : AC(218)

Diseases : Osteoarthritis: Knee : CK(1329) : AC(213)

Therapeutic Actions : Massage/Therapeutic Touch : CK(933) : AC(111)

Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(13987), Interleukin-1 beta downregulation : CK(3041) : AC(2595), Interleukin-6 Downregulation : CK(5029) : AC(3255), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(4342)