n/a
Article Publish Status: FREE
Abstract Title:

Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar RatsTheir Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2.

Abstract Source:

Oxid Med Cell Longev. 2022 ;2022:2710607. Epub 2022 Jul 27. PMID: 35936216

Abstract Author(s):

Osama M Ahmed, Mohammed H Elkomy, Hanaa I Fahim, Mohamed B Ashour, Ibrahim A Naguib, Badrah S Alghamdi, Heba Uallah R Mahmoud, Noha A Ahmed

Article Affiliation:

Osama M Ahmed

Abstract:

The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were treated via the oral route with rutin and quercetin (50 mg/kg) either alone or in combination every other day for five weeks concomitant with receiving intraperitoneal DXR (2 mg/kg) two times a week for five successive weeks. Quercetin, rutin, and their combination significantly improved the deteriorated serum AST, ALT, and ALP activities and totalbilirubin level, as well as albumin, AFP, and CA 19.9 levels in DXR-injected rats. Treatments of the DXR-injected group with quercetin and rutin prevented the elevation in liver lipid peroxidation and the reduction in superoxide dismutase, glutathione-S-transferase and glutathione peroxidase activities, and glutathione content. Treatments with quercetin and rutin significantly repressed the elevated expression of liver p53 and TNF-and enhanced Nrf2 expression. Furthermore, the treatments significantly reduced DXR-induced liver histological changes. In conclusion, rutin and quercetin either alone or in combination may have potential preventive effects against DXR-induced hepatotoxicity through inhibiting oxidative stress, inflammation, and apoptosis as well as modulating the Nrf2 expression.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.