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Abstract Title:

Royal jelly reduce DNA damage induced by alkylating agent in mice.

Abstract Source:

Mutat Res. 2022 Aug 20 ;825:111796. Epub 2022 Aug 20. PMID: 36007462

Abstract Author(s):

Adriani Paganini Damiani, Marina Lummertz Magenis, Ligia Salvan Dagostin, Ângela Caroline da Luz Beretta, Rovena Jacobsen Sarter, Luiza Martins Longaretti, Isadora de Oliveira Monteiro, Vanessa Moraes de Andrade

Article Affiliation:

Adriani Paganini Damiani

Abstract:

Royal jelly (RJ) is a creamy white-yellow liquid that is secreted by the mandibular and hypopharyngeal glands of bees to nourish the larvae. RJ has gained increasing interest in recent years owing to its antioxidant potential. However, little is known about adequate RJ dosing and its effects on genetic material. Thus, the aim of this study was to evaluate the in vivo effects of RJ on genotoxicity and mutagenicity induced by the alkylating agent methyl methanesulfonate (MMS). In this study, 3-month-old Swiss albino male mice (N = 66) were divided into 11 groups for experimentation. Experiments were performed by administering lyophilized RJ (150 mg/kg, 300 mg/kg, and 1000 mg/kg) or water via gavage as pre- and posttreatment processes with the alkylating agent MMS. After treatment, blood samples were collected from themice via an incision at the end of the tail to conduct comet assays at times of 24 h and 48 h posttreatment. The mice were then euthanized to remove the bone marrow for a micronucleus test. Overall, regardless of dose, RJ did not exhibit genotoxic, mutagenic activity and the administration of high doses, mainly in the form of posttreatment, presented antigenotoxic and antimutagenic actions. Further, a dose-response correlation was observed in the RJ posttreatment groups. These results demonstrate that RJ administration was effective in reversing the damage caused by the alkylating agent MMS.

Study Type : Animal Study

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