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Article Publish Status: FREE
Abstract Title:

Impact of Bee Venom Enzymes on Diseases and Immune Responses.

Abstract Source:

Molecules. 2016 Dec 27 ;22(1). Epub 2016 Dec 27. PMID: 28035985

Abstract Author(s):

Md Sakib Hossen, Ummay Mahfuza Shapla, Siew Hua Gan, Md Ibrahim Khalil

Article Affiliation:

Md Sakib Hossen

Abstract:

Bee venom (BV) is used to treat many diseases and exhibits anti-inflammatory, anti-bacterial, antimutagenic, radioprotective, anti-nociceptive immunity promoting, hepatocyte protective and anti-cancer activity. According to the literature, BV contains several enzymes, including phospholipase A2 (PLA2), phospholipase B, hyaluronidase, acid phosphatase andα-glucosidase. Recent studies have also reported the detection of different classes of enzymes in BV, including esterases, proteases and peptidases, protease inhibitors and other important enzymes involved in carbohydrate metabolism. Nevertheless, the physiochemical properties and functions of eachenzyme class and their mechanisms remain unclear. Various pharmacotherapeutic effects of some of the BV enzymes have been reported in several studies. At present, ongoing research aims to characterize each enzyme and elucidate their specific biological roles. This review gathers all the current knowledge on BV enzymes and their specific mechanisms in regulating various immune responses and physiological changes to provide a basis for future therapies for various diseases.

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