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Abstract Title:

Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells via Upregulation of YAP Expression in Inflammatory Environment.

Abstract Source:

Stem Cells Dev. 2021 Oct 1. Epub 2021 Oct 1. PMID: 34598655

Abstract Author(s):

Zihan Wang, Le Li, Wenwen Gu, Yuqi Mao, Tao Wang

Article Affiliation:

Zihan Wang

Abstract:

Osteoporosis is an age-related bone disease, characterized by rapid bone loss, decreased bone mineral density (BMD), and consequent risk of fractures. The most prevalent form of clinically significant osteoporosis involves various inflammatory conditions, especially age-dependent osteoporosis and postmenopausal osteoporosis. Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, plays a critical role in the development of inflammatory, which also plays an important role in bone formation and bone loss during osteoporosis. In this report, we examined the effect of TNF-α on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and its modulation by resveratrol. We found that TNF-α can upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment. High inflammatory cytokine expression significantly inhibited osteogenic differentiation of BMSCs by overactivating upstreamHippo kinases and decreasing the nuclear YAP signals. With resveratrol (Res) treatment, decreasing inflammatory cytokine expression normalized Hippo/YAP signaling and effectively rescued YAP-mediated osteogenesis. Thus, through these studies, we present a mechanism by which TNF-α can affect BMSCsosteogenesis through modulation of Hippo/YAP signaling.

Study Type : In Vitro Study

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