Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes. - GreenMedInfo Summary

Abstract Title:

Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro.

Abstract Source:

Mutat Res Genet Toxicol Environ Mutagen. 2016 Aug ;806:40-6. Epub 2016 Jul 11. PMID: 27476334

Abstract Author(s):

Emiliano Basso, Giulia Regazzo, Mario Fiore, Valentina Palma, Gianandrea Traversi, Antonella Testa, Francesca Degrassi, Renata Cozzi

Article Affiliation:

Emiliano Basso

Abstract:

Resveratrol (3,4',5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histone deacetylase activity.

Article Published Date : Jul 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol : CK(2037) : AC(1449)

Diseases : DNA damage : CK(1997) : AC(789)

Pharmacological Actions : Genoprotective : CK(513) : AC(197), Radioprotective : CK(1668) : AC(638)

Anti Therapeutic Actions : Low Dose Ionizing Radiation : CK(61) : AC(30)