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Abstract Title:

Protective effects of rutin and chlorogenic acid against antihypoxic conditions in mice.

Abstract Source:

Pak J Pharm Sci. 2021 Sep ;34(5):1679-1683. PMID: 34803002

Abstract Author(s):

Fatemeh Masoomzadeh, Barkat Ali Khan, Sultan M Alshahrani, Ali Alqahtani, Mohammad Ali Ebrahimzadeh, Masomeh Khalili

Article Affiliation:

Fatemeh Masoomzadeh

Abstract:

Almost all plants contain polyphenols. Literature shows that polyphenols exhibit many biological activities. Little has known about their protective effects against hypoxia-induced lethality. The protective effects of rutin (1) and chlorogenic acid (2) against hypoxia conditions in mice were determined by three different experimental models. Antihypoxic activity was especially pronounced in asphytic hypoxia. Both compounds (1&2) showed statistically significant (p>0.05) activities respect to the control. Compound (1) significantly prolonged the latency for death with respect to control (39.20±8.70 vs. 13.20±2.58min, p<0.001). Compound (1) was the most effective compound in circulatory hypoxia. It significantly prolonged the latency for death with respect to control (14.44±2.82 vs. 9.82±0.79 min, p<0.01). On the other hand, Chlorogenic acid (2) at a dose of 100 mg kgkept mice alive for 12.76±1.30min (p>0.05). None of two phenolic acids had any activity in haemic hypoxia when compared to control.

Study Type : Animal Study

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