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Article Publish Status: FREE
Abstract Title:

Protective effect of taxifolin against prooxidant and proinflammatory kidney damage associated with acrylamide in rats.

Abstract Source:

Biomed Pharmacother. 2021 Jul ;139:111660. Epub 2021 May 11. PMID: 34243628

Abstract Author(s):

Fevzi Bedir, Hüseyin Kocatürk, Turgut Yapanoğlu, Cebrail Gürsul, Remzi Arslan, Renad Mammadov, Abdülkadir Çoban, Durdu Altuner, Halis Suleyman

Article Affiliation:

Fevzi Bedir

Abstract:

The current study investigates the biochemical and histopathological effects of taxifolin on acrylamide-induced kidney damage. A 50 mg/kg dose of taxifolin was administered via oral gavage to the taxifolin + acrylamide (TACR) group (n-6) consisting of male albino Wistar rats. The same volume of distilled water used as solvent was orally administered to the acrylamide (ACR) (n-6) and healthy (HG) (n-6) groups. One hour afterthe administration of taxifolin and distilled water, a 20 mg/kg dose of acrylamide was orally administered to the TACR and ACR groups. This procedure was repeated once a day for 30 days. In the acrylamide group, malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) levels were found to be high, total glutathione (tGSH) levels were found to be low, and there was severe interstitial haemorrhage; additionally, tubular necrosis, tubular atrophy, leucocyte infiltration, and glomerular structures with expanded Bowman's space were observed. In the taxifolin group, where the increase of MDA, IL-1β, and TNF-α and the decrease of tGSH associated with acrylamide have been prevented, any histopathological finding other than mild necrosis and atrophic tubules was not found. This suggests that Taxifolin would prevent kidney tissue from acrylamide-induced damage would be effective in treating acrylamide-induced nephrotoxicity, inhibiting the increase of MDA, IL-1β and TNF-α, and decreasing tGSH associated with acrylamide.

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