Propolis is an inhibitor of Candida virulence factors and represents an innovative alternative to fight candidiasis. - GreenMedInfo Summary

Abstract Title:

Propolis: a potential natural product to fight Candida species infections.

Abstract Source:

Future Microbiol. 2016 Aug 9. Epub 2016 Aug 9. PMID: 27501739

Abstract Author(s):

Flávia K Tobaldini-Valerio, Patricia S Bonfim-Mendonça, Helen C Rosseto, Marcos L Bruschi, Mariana Henriques, Melyssa Negri, Sonia Silva, Terezinha Ie Svidzinski

Article Affiliation:

Flávia K Tobaldini-Valerio

Abstract:

AIM: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms.

MATERIALS & METHODS: The MIC values, time-kill curves and filamentation form inhibition were determined in Candida planktonic cells. The effect of propolis on Candida biofilms was assessed through quantification of CFUs.

RESULTS: MIC values, ranging from 220 to 880µg/ml, demonstrated higher efficiency on C. albicans and C. parapsilosis than on C. tropicalis cells. In addition, propolis was able to prevent Candida species biofilm's formation and eradicate their mature biofilms, coupled with a significant reduction on C. tropicalis and C. albicans filamentation.

CONCLUSION: Propolis is an inhibitor of Candida virulence factors and represents an innovative alternative to fight candidiasis.

Article Published Date : Aug 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bee Propolis : CK(861) : AC(286)
Diseases : Candida Albicans, Candida Infection : CK(389) : AC(218)
Pharmacological Actions : Anti-Bacterial Agents : CK(2894) : AC(1816)
Additional Keywords : Biofilm : CK(128) : AC(89)

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Key Research Topics

Substance

Bee Propolis

Pharmacological Actions

Anti-Bacterial Agents

Disease

Candida Infection
Candida Albicans

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