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Article Publish Status: FREE
Abstract Title:

Prevention of High-Fat Diet-Induced Hypercholesterolemia byFn041 Through Promoting Cholesterol and Bile Salt Excretion and Intestinal Mucosal Barrier Functions.

Abstract Source:

Front Nutr. 2022 ;9:851541. Epub 2022 Mar 11. PMID: 35369106

Abstract Author(s):

Mengyao Lu, Jin Sun, Yuning Zhao, Haowen Zhang, Xinyue Li, Jingbo Zhou, Hongyang Dang, Jidong Zhang, Wenjing Huang, Ce Qi, Duo Li

Article Affiliation:

Mengyao Lu

Abstract:

Objectives: Fn041 (Fn041) is a probiotic isolated from immunoglobulin A coated microbiota in the human breast milk of Gannan in China with a low incidence of hypercholesterolemia. This study aims to explore the role and mechanism of Fn041 in preventing hypercholesterolemia caused by a high-fat diet in mice.

Methods: C57BL/6N mice were fed a low-fat diet or a high-fat diet and gavage with Fn041 andGG (LGG) for 8 weeks.

Results: Both Fn041 and LGG prevented the occurrence of hypercholesterolemia, liver and testicular fat accumulation. In addition, a high-fat diet causes intestinal dysbiosis and mucosal barrier damage, which is associated with hypercholesterolemia. Fn041 prevented the high-fat diet-induced reduction in alpha diversity of intestinal microbiota and intestinal mucosal barrier damage. Fn041 treatment significantly increased fecal total cholesterol and total bile acids.

Conclusions: Fn041 prevented hypercholesterolemia by enhancing cholesterol excretion and mucosal barrier function.

Study Type : Animal Study

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