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Article Publish Status: FREE
Abstract Title:

Palmitoylethanolamide: A Natural Compound for Health Management.

Abstract Source:

Int J Mol Sci. 2021 May 18 ;22(10). Epub 2021 May 18. PMID: 34069940

Abstract Author(s):

Paul Clayton, Mariko Hill, Nathasha Bogoda, Silma Subah, Ruchitha Venkatesh

Article Affiliation:

Paul Clayton

Abstract:

All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA's actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA's poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management.

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