Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression. - GreenMedInfo Summary

Article Publish Status: FREE

Click here to read the complete article.

Abstract Title:

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo.

Abstract Source:

Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID: 27121041

Abstract Author(s):

Wei Kevin Zhang, Shan-Shan Tao, Ting-Ting Li, Yu-Sang Li, Xiao-Jun Li, He-Bin Tang, Ren-Huai Cong, Fang-Li Ma, Chu-Jun Wan

Article Affiliation:

Wei Kevin Zhang

Abstract:

BACKGROUND: Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain.

METHODS AND RESULTS: Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree.

CONCLUSIONS: We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nutmeg : CK(58) : AC(38)

Diseases : Allodynia : CK(26) : AC(41), Chronic Pain : CK(1018) : AC(212), Inflammation : CK(9572) : AC(4849)

Pharmacological Actions : Analgesics : CK(3498) : AC(943), Anti-Inflammatory Agents : CK(20859) : AC(13987), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(1223)

Additional Keywords : Superiority of Natural Substances versus Drugs : CK(1644) : AC(387)

Problem Substances : Diclofenac : CK(228) : AC(50)