Article Publish Status: FREE
Abstract Title:

Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences.

Abstract Source:

Front Pharmacol. 2021 ;12:688490. Epub 2021 Jun 2. PMID: 34149431

Abstract Author(s):

Jing Li, Qingxia Huang, Jinjin Chen, Hongyu Qi, Jiaqi Liu, Zhaoqiang Chen, Daqing Zhao, Zeyu Wang, Xiangyan Li

Article Affiliation:

Jing Li


Alzheimer's disease (AD), a neurodegenerative disorder, is a major health concern in the increasingly aged population worldwide. Currently, no clinically effective drug can halt the progression of AD.C.A. Meyis a well-known medicinal plant that contains ginsenosides, gintonin, and other components and has neuroprotective effects against a series of pathological cascades in AD, including beta-amyloid formation, neuroinflammation, oxidative stress, and mitochondrial dysfunction. In this review, we summarize the effects and mechanisms of these major components and formulas containingin neuronal cells and animal models. Moreover, clinical findings regarding the prevention and treatment of AD withor its formulas are discussed. This review can provide new insights into the possible use of ginseng in the prevention and treatment of AD.

Study Type : Review

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