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Abstract Title:

Myricitrin - a flavonoid isolated from the Indian olive tree () - inhibits Monoamine oxidase in the brain and elevates striatal dopamine levels: therapeutic implications against Parkinson's disease.

Abstract Source:

Food Funct. 2022 Jun 20 ;13(12):6545-6559. Epub 2022 Jun 20. PMID: 35647619

Abstract Author(s):

Chayan Banerjee, Sumangal Nandy, Joy Chakraborty, Deepak Kumar

Article Affiliation:

Chayan Banerjee

Abstract:

Flavonoids exhibit several biological activities including inhibition of Monoamine oxidase (MAO), an enzyme that metabolizes several neurotransmitters. Thus, MAO inhibitors are well included in traditional therapeutic practices to fine-tune neuromotor behavior. This study aims to isolate flavonoids from a less explored plant of northeast India, named Indian olive (; Ef, family Elaeocarpaceae), and evaluate their MAO inhibitory properties. Four flavonoids from Ef leaf extract, namely, myricitrin, mearnsitrin, myricetin, and mearnsetin, are taken into consideration. Spectrofluorimetric assay is carried out to determine the MAO inhibitory properties. Next,andtoxicity studies are performed in neuronal cell line and, respectively. Furthermore, MAO inhibition by the selected compounds and their effect on dopamine levels are examined in the mouse brain. We evaluated the therapeutic potential in a mouse model of Parkinson's disease (PD) in terms of behavior, neurotransmitter levels, and dopaminergic neuronal loss. In ansetup, all four compounds inhibited total MAO, whereas myricitrin exhibited some selectivity against MAO-B at 100μM. Myricitrin and mearnsitrin exhibited no toxicity,or. However, only myricitrin inhibited MAO in the mouse brain and elevated dopamine levels. Myricitrin was able to attenuate motor incoordination in the mouse model of PD and improved dopamine levels in the striatum.

Study Type : Animal Study

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