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Article Publish Status: FREE
Abstract Title:

The modulatory properties oftreatment on endometrial cancer: an integrated pharmacological method.

Abstract Source:

PeerJ. 2021 ;9:e11995. Epub 2021 Aug 24. PMID: 34513331

Abstract Author(s):

Qianqian Zhang, Xianghua Huang

Article Affiliation:

Qianqian Zhang

Abstract:

is a traditional Chinese medicine and has been used for adjuvant clinical therapy for a variety of cancers. However, the mechanism of its action on endometrial carcinoma is unclear. Based on the Gene Expression Omnibus (GEO) database, the Cancer Genome Atlas (TCGA) database, and the Traditional Chinese Medicine System Pharmacology Database (TCMSP™), the drug and target compounds were initially screened to construct a common network module. Twenty active compounds inwere successfully identified, which hit by 463 potential targets related to endometrial cancer. Eight of the more highly predictive compounds (such as Jaranol, Bifendate, Isorhamnetin, Calycosin, 7-O-methylisomucronulatol, Formononetin, Kaempferol, Quercetin) were involved in DNA integrity checkpoint, cyclin-dependent protein kinase holoenzyme complex, and histone kinase activity. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway confirmed thatmight play a role in the treatment of endometrial cancer through p53 signalling pathway, transcriptional misregulation in cancer, and endometrial cancer signalling pathway. Drug-target-pathway networks were constructed using Cytoscape to provide a visual perspective. In addition, we verified that formononetin inhibited the proliferation of endometrial cancer cells through cell viability tests and clone formation tests. And qPCR and western blot found that formononetin exerts anti-cancer effects by promoting the expression of estrogen receptor beta (ER) and p53. Based on a systematic network pharmacology approach, our works successfully predict the active ingredients and potential targets offor application to endometrial cancer and helps to illustrate mechanism of action on a comprehensive level.

Study Type : In Vitro Study

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