n/a

Article Publish Status: FREE
Abstract Title:

Memory-Enhancing Effects ofEssential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study.

Abstract Source:

Antioxidants (Basel). 2020 Sep 26 ;9(10). Epub 2020 Sep 26. PMID: 32993114

Abstract Author(s):

Paula Alexandra Postu, Dragos Lucian Gorgan, Oana Cioanca, Manuela Russ, Stefan Mikkat, Michael Otto Glocker, Lucian Hritcu

Article Affiliation:

Paula Alexandra Postu

Abstract:

L. (Lamiaceae) is an important genus of medicinal and aromatic plants used in traditional medicine since ancient times as culinary herbs and remedies. The aim of the present study was to evaluate the chemical composition, as well as the biochemical and cellular activities of freshly preparedL. essential oil (OmEO) in an Alzheimer's disease (AD) amyloid beta1-42 (Aβ1-42) rat model. OmEO (1% and 3%) was inhaled for 21 consecutive days, while Aβ1-42 was administered intracerebroventricularly to induce AD-like symptoms. Our data demonstrate that OmEO increased antioxidant activity and enhanced brain-derived neurotrophic factor (BDNF) expression, which in concert contributed to the improvement of cognitive function of animals. Moreover, OmEO presented beneficial effects on memory performance in Y-maze and radial arm-maze tests in the Aβ1-42 rat AD model.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.