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Abstract Title:

Lung inflammation from repeated exposure to LPS and glyphosate.

Abstract Source:

Cell Tissue Res. 2021 Oct 9. Epub 2021 Oct 9. PMID: 34626244

Abstract Author(s):

Upkardeep Pandher, Shelley Kirychuk, David Schneberger, Brooke Thompson, Gurpreet Aulakh, R S Sethi, Baljit Singh

Article Affiliation:

Upkardeep Pandher

Abstract:

Agricultural workplaces consist of multiple airborne contaminants and inhalation exposures induce respiratory effects in workers. Endotoxin (LPS) and glyphosate are two common airborne contaminants in agricultural environments. We have previously shown that exposure to a combination of LPS and glyphosate synergistically modulates immune reactions as compared to individual exposures. The immunopathogenesis of acute and chronic exposure to complex agricultural exposures including LPS and glyphosate is not known; therefore, we further investigated the lung cellular inflammatory differences in mice exposed to either a combination, or individual, LPS, and glyphosate for 1 day, 5 days, and 10 days. Exposure to a combination of LPS and glyphosate resulted in greater cellular inflammatory effects in lungs as compared to individual exposures to LPS or glyphosate. Repeated exposures to the combination of LPS and glyphosate resulted in robust infiltration of inflammatory cells in the perivascular, peribronchiolar, and alveolar regions, and increases of alveolar septal thicknesses and perivascular spaces in the lungs with intense intercellular adhesion molecule (ICAM) - 1 staining in the perivascular region, but minimal staining in the pulmonary artery endothelium.

Study Type : Animal Study

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