n/a
Abstract Title:

Lower circulating zinc and selenium levels are associated with an increased risk of asthma: evidence from a meta-analysis.

Abstract Source:

Public Health Nutr. 2019 Nov 5:1-8. Epub 2019 Nov 5. PMID: 31685060

Abstract Author(s):

Meng Chen, Yongye Sun, Yili Wu

Article Affiliation:

Meng Chen

Abstract:

OBJECTIVE: Previous studies evaluating the associations of circulating Zn and Se levels with asthma have produced inconsistent results. Therefore, we conducted a meta-analysis to summarize and quantitatively synthesize the evidence from observational research.

DESIGN: Meta-analysis.

SETTING: We searched PubMed, Web of Science and Scopus databases up to May 2019 for relevant available articles. Random-effects model was adopted to estimate the pooled standardized mean difference (SMD) with 95 % CI. Meta-regression analysis and 'leave-one-out' sensitivity analysis were used to assess heterogeneity.

PARTICIPANTS: The meta-analysis focused on general populations.

RESULTS: A total of twenty-six studies for Zn and forty studies for Se were included in the meta-analysis. The overall analyses identified that asthma patients had lower Zn (SMD = -0·40; 95 % CI -0·77, -0·03; I2 = 94·1 %) and Se (SMD = -0·32; 95 % CI -0·48, -0·17; I2 = 90·9 %) levels in serum or plasma compared with healthy controls. After removing the studies that contributed to the heterogeneity, the pooled SMD were -0·26 (95 % CI -0·40, -0·13; I2 = 37·42 %) for Zn and -0·06 (95 % CI -0·13, 0·02; I2 = 43·54 %) for Se.

CONCLUSIONS: Lower circulating Zn and Se levels might be associated with an increased risk of asthma.

Study Type : Meta Analysis

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.