Licochalcone A-loaded solid lipid nanoparticles improve antischistosomal activity. - GreenMedInfo Summary
Licochalcone A-loaded solid lipid nanoparticles improve antischistosomal activityand.
Nanomedicine (Lond). 2021 08 ;16(19):1641-1655. Epub 2021 Jul 14. PMID: 34256609
Lívia Mara Silva
To isolate licochalcone A (LicoA) from licorice, prepare LicoA-loaded solid lipid nanoparticles (L-SLNs) and evaluate the L-SLNsandagainst.LicoA was obtained by chromatographic fractionation and encapsulated in SLNs by a modified high shear homogenization method.L-SLNs showed high encapsulation efficiency, with satisfactory particle size, polydispersity index and Zeta potential. Transmission electron microscopy revealed that L-SLNs were rounded and homogenously distributed. Toxicity studies revealed that SLNs decreased the hemolytic and cytotoxic properties of LicoA. Treatment with L-SLNs showedefficacy against.L-SLNs are efficient in reducing worm burden and SLNs may be a promising delivery system for LicoA to treatinfections.