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Abstract Title:

improves lipogenesis and IRS-1/AKT/eNOS signalling pathway in the liver of high-fructose-fed rats.

Abstract Source:

Arch Physiol Biochem. 2020 Feb 18:1-9. Epub 2020 Feb 18. PMID: 32067511

Abstract Author(s):

Esra Sumlu, Aykut Bostancı, Gökhan Sadi, Mehmet Eray Alçığır, Fatma Akar

Article Affiliation:

Esra Sumlu

Abstract:

In the present study, we investigated the influence ofandsupplementation on lipogenesis, insulin signalling and glucose transporters in liver of high-fructose-fed rats. Fructose was given to the rats as a 20% solution in drinking water for 15 weeks.andsupplementations were performed by gastric gavage once a day during final 6 weeks. Dietary high-fructose increased hepatic weight, lipid accumulation and FASN expression as well as caused a significant reduction in IRS-1 expression, pAKT/total AKT and peNOS/total eNOS ratios, but an elevation in GLUT2 and GLUT5 mRNAs in the liver.supplementation decreased hepatic weight, triglyceride content and FASN expression as well as improved IRS-1/AKT/eNOS pathway and GLUT2 expression in the liver of high-fructose-fed rats. However,supplementation exerted a restoring effect on lipid accumulation by decreasing FASN expression, and regulating effect on IRS-1 and GLUT2 expressions.

Study Type : Animal Study

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