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Article Publish Status: FREE
Abstract Title:

DG enhances the lactoferrin anti-SARS-CoV-2 response in Caco-2 cells.

Abstract Source:

Gut Microbes. 2021 Jan-Dec;13(1):1961970. PMID: 34365895

Abstract Author(s):

Claudio Salaris, Melania Scarpa, Marina Elli, Alice Bertolini, Simone Guglielmetti, Fabrizio Pregliasco, Paola Brun, Ignazio Castagliuolo

Article Affiliation:

Claudio Salaris

Abstract:

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing global pandemic of coronavirus disease 2019 (COVID-19), which primarily manifests with respiratory distress and may also lead to symptoms associated with the gastrointestinal tract. Probiotics are living microorganisms that have been shown to confer immune benefits. In this study, we investigated the immunomodulatory effects and anti-SARS-CoV-2 activity of three differentprobiotic strains, either alone or in combination with lactoferrin, using the intestinal epithelial Caco-2 cell line. Our results revealed that theDG strain significantly induced the expression of genes involved in protective antiviral immunity and prevented the expression of proinflammatory genes triggered by SARS-CoV-2 infection. Moreover,DG significantly inhibited SARS-CoV-2 infectionDG also positively affected the antiviral immune activity of lactoferrin and significantly augmented its anti-SARS-CoV-2 activity in Caco-2 intestinal epithelial cells. Overall, our work shows that the probiotic strainDG is a promising candidate that exhibits prophylactic potential against SARS-CoV-2 infection.

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