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Abstract Title:

Regulation divergences ofPCC and431 on penicillin-induced upper respiratory tract microbial dysbiosis in BALB/c mice.

Abstract Source:

Food Funct. 2021 Nov 29 ;12(23):11913-11925. Epub 2021 Nov 29. PMID: 34739535

Abstract Author(s):

Feng Gao, Zhifeng Fang, Wenwei Lu

Article Affiliation:

Feng Gao

Abstract:

Antibiotic-induced host health imbalance during upper respiratory tract infection (URTI) treatment is an emerging issue. Studies have confirmed that431 andPCC alleviate gut microbiome dysbiosis and improve immune response. However, their effect on the upper respiratory tract (URT) microbial structure and the correlation between the URT microbiota and immunological indicators remain unclear. To evaluate the effects ofstrains on restoring penicillin-induced imbalance in the URT microbiome and on immune response,PCC and431 were individually administered to penicillin-pretreated mice, and their effects were assessed. The results revealed that431 andPCC could regulate the systemic immune response imbalance, but the regulation direction ofPCC was closer to that of the control group. Moreover, thestrains could restore penicillin-induced URT dysbacteriosis in the microbial community structure, but no significant change in alpha diversity was observed. The key bacterial taxa modulated by431 were,, and.PCC enhanced biofilms and facultatively anaerobic bacteria. Different regulation pathways were observed in the two strains, and RDA revealed that both431 andPCC groups were correlated with IL-17 and IL-1α, while the431 group was also correlated with IL-6. In conclusion,431 andPCC could beneficially and differentially ameliorate penicillin-induced imbalance in the URT microbial composition structure and functional metabolic pathways and modulate immune response, reflecting strain-specific regulation.

Study Type : Animal Study

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