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Article Publish Status: FREE
Abstract Title:

The HS-Donor Erucin Exhibits Protective Effects against Vascular Inflammation in Human Endothelial and Smooth Muscle Cells.

Abstract Source:

Antioxidants (Basel). 2021 Jun 15 ;10(6). Epub 2021 Jun 15. PMID: 34203803

Abstract Author(s):

Alma Martelli, Eugenia Piragine, Era Gorica, Valentina Citi, Lara Testai, Eleonora Pagnotta, Luca Lazzeri, Nicola Pecchioni, Valerio Ciccone, Rosangela Montanaro, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Vincenzo Brancaleone, Lucia Morbidelli, Vincenzo Calderone

Article Affiliation:

Alma Martelli

Abstract:

Preservation of vascular wall integrity against degenerative processes associated with ageing, fat-rich diet and metabolic diseases is a timely therapeutical challenge. The loss of endothelial function and integrity leads to cardiovascular diseases and multiorgan inflammation. The protective effects of the HS-donor erucin, an isothiocyanate purified byMill. seeds, were evaluated on human endothelial and vascular smooth muscle cells. In particular, erucin actions were evaluated on cell viability, ROS, caspase 3/7, inflammatory markers levels and the endothelial hyperpermeability in an inflammatory model associated with high glucose concentrations (25 mM, HG). Erucin significantly prevented the HG-induced decrease in cell viability as well as the increase in ROS, caspase 3/7 activation, and TNF-α and IL-6 levels. Similarly, erucin suppressed COX-2 and NF-κB upregulation associated with HG exposure. Erucin also caused a significant inhibition of p22phox subunit expression in endothelial cells. In addition, erucin significantly prevented the HG-induced increase in endothelial permeabilityas also confirmed by the quantification of the specific markers VE-Cadherin and ZO-1. In conclusion, our results assess anti-inflammatory and antioxidant effects by erucin in vascular cells undergoing HG-induced inflammation and this protection parallels the preservation of endothelial barrier properties.

Study Type : In Vitro Study

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