Glutathione inhibits trace metal-induced prophyrias. - GreenMedInfo Summary

Abstract Title:

Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metals.

Abstract Source:

Biochem Biophys Res Commun. 1988 May 16;152(3):1428-34. PMID: 3132158

Abstract Author(s):

J S Woods

Abstract:

We have employed a model in vitro system for iron-peroxide-catalyzed oxidation of porphyrinogens to investigate the potential role of glutathione (GSH) in trace metal-induced porphyrias. GSH strongly attenuates porphyrinogen oxidation at biologically relevant concentrations in a dose-dependent manner. Porphyrinogenic trace metals reduce the effectiveness of GSH as a porphyrinogen antioxidant, leading to significantly higher rates of porphyrinogen oxidation to porphyrins. These observations may, in part, underlie the etiology of porphyrinurias induced during prolonged trace metal exposures.

Article Published Date : May 16, 1988
Study Type : Commentary
Additional Links
Substances : Glutathione : CK(151) : AC(46)
Diseases : Porphyrias : CK(55) : AC(9)

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Key Research Topics

Substance

Glutathione

Disease

Porphyrias

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