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Abstract Title:

Effects of fucoidans and alginates fromon allergic symptoms and intestinal microbiota in mice with OVA-induced food allergy.

Abstract Source:

Food Funct. 2022 Jun 20 ;13(12):6702-6715. Epub 2022 Jun 20. PMID: 35660845

Abstract Author(s):

Lan Huang, Qianhui Zeng, Yudie Zhang, Qing Yin, Xunxian Zhu, Peixi Zhang, Cuifang Wang, Jieqing Liu

Article Affiliation:

Lan Huang

Abstract:

Food allergy has been one of the main problems threatening people's health in recent years. However, there is still no way to completely cure it at present. Therefore, the development of food allergy related drugs is still necessary.(SG) is a kind of polysaccharide rich marine brown alga used in food and medicine.polysaccharides (SGP) is mainly composed of fucoidans and alginic acid. In our study, we compared the activity of fucoidans and alginates from SG against OVA-induced food allergy in a mouse model, observed the regulatory effects of fucoidans and alginates from SG on the intestinal microbiota and summarized the possible role of the intestinal microbiota in the anti-food allergy process because polysaccharides can further act on the body through the intestinal microbiota. The results showed that fucoidans and alginates from SG could relieve the symptoms of allergy, diarrhea and jejunum injury significantly in mice with food allergy (<0.05). Furthermore, fucoidans at 500 mg kgcould reduce OVA-specific IgE and TNF-α levels significantly in the serum of food allergic mice (<0.05), while alginates could only significantly down-regulate serum OVA-specific IgE (<0.05). The results also showed that fucoidans had a stronger regulatory effect on the richness and diversity of the intestinal microbiota in food allergic mice compared to alginates at the same dose. In addition, fucoidans at 500 mg kghad the most significant regulatory effect on,andin food allergic mice. These results suggested that fucoidans and alginates might regulate food allergy in mice through different pathways. Together, this study enriched the research on the action of alga-derived polysaccharides against food allergy.

Study Type : Animal Study

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