n/a
Article Publish Status: FREE
Abstract Title:

Fucoidan-Rich Substances fromImprove Trimethyltin-Induced Cognitive Dysfunction via Down-Regulation of Amyloidβ Production/Tau Hyperphosphorylation.

Abstract Source:

Mar Drugs. 2019 Oct 17 ;17(10). Epub 2019 Oct 17. PMID: 31627432

Abstract Author(s):

Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Seul Ki Yoo, Hye Ju Han, Dong Hwa Chung, Dae-Ok Kim, Gun-Hee Kim, Ho Jin Heo

Article Affiliation:

Seon Kyeong Park

Abstract:

() was investigated to compare the effect of polyphenol and fucoidan extract and mixture (polyphenol:fucoidan = 4:6) on cognitive function. The ameliorating effect ofwas evaluated using the Y-maze, passive avoidance and Morris water maze tests with a trimethyltin (TMT)-induced cognitive dysfunction model, and the results showed that the fucoidan extract and mixture (4:6) had relatively higher learning and memory function effects than the polyphenol extract. After a behavioral test, the inhibitory effect of lipid peroxidation and cholinergic system activity were examined in mouse brain tissue, and the fucoidan extract and mixture (4:6) also showed greater improvements than the polyphenol extract. Mitochondrial activity was evaluated using mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP,ΔΨm), adenosine triphosphate (ATP) content, and mitochondria-mediated protein (BAX, cytochrome C) analysis, and these results were similar to the results of the behavioral tests. Finally, to confirm the cognitive function-related mechanism of, the amyloid-β production and tau hyperphosphorylation-medicated proteins were analyzed. Based on these results, the improvement effect ofwas more influenced by fucoidan than polyphenol. Therefore, our study suggests that the fucoidan-rich substances incould be a potential material for improving cognitive function by down-regulating amyloid-β production and tau hyperphosphorylation.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.