Abstract Title:

Efficacy of fresh lime for smoking cessation.

Abstract Source:

J Med Assoc Thai. 2012 Dec ;95 Suppl 12:S76-82. PMID: 23513469

Abstract Author(s):

Suthat Rungruanghiranya, Chatchai Ekpanyaskul, Chanin Sakulisariyaporn, Prapada Watcharanat, Kunyanit Akkalakulawas

Article Affiliation:

Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand. [email protected]


OBJECTIVE: To determine the efficacy of fresh lime as a smoking cessation aid compared with nicotine gum.

MATERIAL AND METHOD: A randomized, controlled trial was conducted between March 2009 and September 2009. Only regular smokers aged 18 or older who were willing to quit were randomized to receive either fresh lime (n = 47) or nicotine gum (n = 53). Smokers were excluded if they were using other smoking cessation aids, allergic to citrus, or had dental problems. Exhaled carbon monoxide (CO)-confirmed continuous abstinence rate (CAR) during week 9-12 was measured as the primary outcomes. To grade the severity of craving, a 100-mm visual analogue scale (VAS) was used.

RESULTS: There was no significant difference in CO-confirmed CAR between the fresh lime group and the nicotine gum group during weeks 9-12 (61.7% vs. 66.0%; p = 0.65), although 7-day point prevalence abstinence at week 4 of the fresh lime users was statistically significant lower than those using nicotine gum (38.3% vs. 58.5%; p = 0.04). Cravings did not differ significantly between the groups, although fresh lime users tend to report more cravings intensity.

CONCLUSION: Fresh lime can be used effectively as a smoking cessation aid, although not as good as nicotine gum in reducing cravings.

Study Type : Human Study

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