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Abstract Title:

Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

Abstract Source:

Antiviral Res. 2005 Jul ;67(1):18-23. PMID: 15885816

Abstract Author(s):

Shi-You Li, Cong Chen, Hai-Qing Zhang, Hai-Yan Guo, Hui Wang, Lin Wang, Xiang Zhang, Shi-Neng Hua, Jun Yu, Pei-Gen Xiao, Rong-Song Li, Xuehai Tan

Article Affiliation:

Shi-You Li

Abstract:

More than 200 Chinese medicinal herb extracts were screened for antiviral activities against Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay for virus-induced cytopathic effect (CPE). Four of these extracts showed moderate to potent antiviral activities against SARS-CoV with 50% effective concentration (EC50) ranging from 2.4 +/- 0.2 to 88.2 +/- 7.7 microg/ml. Out of the four, Lycoris radiata was most potent. To identify the active component, L. radiata extract was subjected to further fractionation, purification, and CPE/MTS assays. This process led to the identification of a single substance lycorine as an anti-SARS-CoV component with an EC50 value of 15.7 +/- 1.2 nM. This compound has a CC50 value of 14980.0 +/- 912.0 nM in cytotoxicity assay and a selective index (SI) greater than 900. The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.

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