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Article Publish Status: FREE
Abstract Title:

Evaluation of Antioxidative and Neuroprotective Activities of Total Flavonoids From Sea Buckthorn (L.).

Abstract Source:

Front Nutr. 2022 ;9:861097. Epub 2022 Jun 21. PMID: 35799585

Abstract Author(s):

Zheng Wang, Wenqian Wang, Changlong Zhu, Xiangdong Gao, Weihua Chu

Article Affiliation:

Zheng Wang

Abstract:

The aim of this study was to investigate the antioxidative and neuroprotective activities of total flavonoids from sea buckthorn (L.) (TFH). Results indicated that TFH possessed DPPH radicals, hydroxyl radicals and superoxide anions scavenging activities. The neuroprotective potential was assessed with acetylcholinesterase (AChE) and monoamine oxidase A (MAO-A). The inhibition rates of AChE and MAO-A by 50μg/ml TFH were 75.85 and 51.22%, respectively. Theantioxidative and neuroprotective potential of TFH were explored in. In the longevity assay, TFH (50μg/ml) significantly increased the lifespan of wild-type(29.40%). In the hydrogen peroxide-induced oxidative stress challenge, the antioxidant capacity of TFH-treated wild-typewas significantly enhanced. Themutant strain CL4176 was used to study the neuroprotective effect of TFH. Results showed that TFH significantly delayed paralysis inCL4176. Our study suggested total flavonoids from sea buckthorn (L.) had the potential as an antioxidative and neuroprotective agent to extend aging and treat neurodegenerative diseases.

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