n/a
Article Publish Status: FREE
Abstract Title:

Efficacy and Safety of Sesame Oil Cake Extract on Memory Function Improvement: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Abstract Source:

Nutrients. 2021 Jul 28 ;13(8). Epub 2021 Jul 28. PMID: 34444766

Abstract Author(s):

Su-Jin Jung, Eun-Soo Jung, Ki-Chan Ha, Hyang-Im Baek, Yu-Kyung Park, Soog-Kyoung Han, Soo-Wan Chae, Seung-Ok Lee, Young-Chul Chung

Article Affiliation:

Su-Jin Jung

Abstract:

The goal of treatment for mild cognitive impairment (MCI) is to reduce the existing clinical symptoms, delay the progression of cognitive impairment and prevent the progression to Alzheimer's disease (AD). At present, there is no effective drug therapy for AD treatment. However, early intake of dietary supplements may be effective in alleviating and delaying the MCI. This study aims to evaluate the effects of sesame oil cake extract (SOCE) supplementation on cognitive function in aged 60 years or older adults with memory impairment. A total of 70 subjects received either SOCE (= 35) or placebo (= 35) for 12 weeks based on random 1:1 assignment to these two groups. Cognitive function was evaluated by a computerized neurocognitive function test (CNT), and changes in the concentrations of plasma amyloidβ (Aβ) proteins and urine 8-OHdG (8-hydroxy-2'-deoxyguanosine) were investigated before and after the experiment. Verbal learning test index items of the CNT improved markedly in the SOCE group compared to the placebo group (<0.05). Furthermore, plasma amyloid-β (1-40) and amyloid-β (1-42) levels in the SOCE group decreased significantly compared to that in the placebo group (<0.05). There was no statistically significant difference in urine 8-OHdG between the two groups (>0.05). Collectively, intake of SOCE for 12 weeks appears to have a beneficial effect on the verbal memory abilities and plasmaβ-amyloid levels of older adults with memory impairment.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.