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Article Publish Status: FREE
Abstract Title:

Effects of Genistein on Common Kidney Diseases.

Abstract Source:

Nutrients. 2022 Sep 13 ;14(18). Epub 2022 Sep 13. PMID: 36145144

Abstract Author(s):

Qianwen Peng, Yuanyuan Li, Jia Shang, Haitao Huang, Yiming Zhang, Yueming Ding, Yipei Liang, Zhenxing Xie, Chaoran Chen

Article Affiliation:

Qianwen Peng

Abstract:

Genistein is a naturally occurring phytoestrogen (soy or soybean products) that is classified as an isoflavone, and its structure is similar to that of endogenous estrogens; therefore, genistein can exert an estrogen-like effect via estrogen receptors. Additionally, genistein is a tyrosine kinase inhibitor, which enables it to block abnormal cell growth and proliferation signals through the inhibition of tyrosine kinase. Genistein is also an angiogenesis inhibitor and an antioxidant. Genistein has effects on kidney cells, some of the kidney's physiological functions, and a variety of kidney diseases. First, genistein exerts a protective effect on normal cells by reducing the inflammatory response, inhibiting apoptosis, inhibiting oxidative stress, inhibiting remodeling, etc., but after cell injury, the protective effect of genistein decreases or even has the opposite effect. Second, genistein can regulate renin intake to maintain blood pressure balance, regulate calcium uptake to regulate Caand Pi balances, and reduce vasodilation to promote diuresis. Third, genistein has beneficial effects on a variety of kidney diseases (including acute kidney disease, kidney cancer, and different chronic kidney diseases), such as reducing symptoms, delaying disease progression, and improving prognosis. Therefore, this paper reviews animal and human studies on the protective effects of genistein on the kidney in vivo and in vitro to provide a reference for clinical research in the future.

Study Type : Review
Additional Links
Pharmacological Actions : Renoprotective : CK(2404) : AC(1762)

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