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Article Publish Status: FREE
Abstract Title:

Effects of curcumin on low-density lipoprotein oxidation: From experimental studies to clinical practice.

Abstract Source:

EXCLI J. 2022 ;21:840-851. Epub 2022 Jun 22. PMID: 36110563

Abstract Author(s):

Fatemeh Baratzadeh, Alexandra E Butler, Prashant Kesharwani, Seyed Adel Moallem, Amirhossein Sahebkar

Article Affiliation:

Fatemeh Baratzadeh

Abstract:

Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxidative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.

Study Type : Review

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