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Abstract Title:

Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice.

Abstract Source:

Planta Med. 2008 Mar ;74(4):377-80. PMID: 18484526

Abstract Author(s):

Yong-Ming Cui, Ming-Zhang Ao, Wei Li, Long-Jiang Yu

Article Affiliation:

Yong-Ming Cui

Abstract:

Glabridin was isolated from the roots of Glycyrrhiza glabra and its effects on cognitive functions and cholinesterase activity were investigated in mice. Glabridin (1, 2 and 4 mg kg (-1), P. O.) and piracetam (400 mg kg (-1), i. p.), a clinically used nootropic agent, were administered daily for 3 successive days to different groups of mice. The higher doses (2 and 4 mg kg (-1), P. O.) of glabridin and piracetam significantly antagonized the amnesia induced by scopolamine (0.5 mg kg (-1), I. P.) in both the elevated plus maze test and passive avoidance test. Furthermore, glabridin (2 and 4 mg kg (-1), P. O.) and metrifonate (50 mg kg (-1), I. P.), used as a standard drug, both remarkably reduced the brain cholinesterase activity in mice compared to the control group. Therefore, glabridin appears to be a promising candidate for memory improvement and it will be worthwhile to explore the potential of glabridin in the management of Alzheimer patients.

Study Type : Animal Study

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