n/a
Abstract Title:

The effect of cranberry supplementation on Helicobacter pylori eradication inpositive subjects:.

Abstract Source:

Br J Nutr. 2021 Oct 21:1-33. Epub 2021 Oct 21. PMID: 34670631

Abstract Author(s):

Ronak Nikbazm, Zahra Rahimi, Yousef Moradi, Meysam Alipour, Farzad Shidfar

Article Affiliation:

Ronak Nikbazm

Abstract:

Helicobacter pylori infection is one of the most common chronic bacterial infections. Cranberry has been suggested for Helicobacter pylori eradication. We aimed to conduct the first meta-analysis to summarize current evidence on effects of cranberry supplementation on Helicobacter pylori eradication in H. pylori positive subjects. We searched the online databases up to December 2020. Four randomized clinical trials (RCTs) were included with human subjects, investigating the effect of cranberry on Helicobacter pylori eradication. The pooled results were expressed as the odds ratio with 95% confidence intervals. Based on 5 effect sizes with a total sample size of 1935 individuals, we found that according to the odds ratio, there was a positive effect of cranberry supplementation on Helicobacter pylori eradication, increasing the chance of Helicobacter pylori eradication by 1.27 times, but this relationship was not statistically significant (overall OR: 1.27; 95% CI: 0.63, 2.58). The results also indicated the moderate between-study heterogeneity (I2=63.40%; P=0.03) of the studies. However, there were no significant differences in some subgroup analyses in the duration of treatment, the duration of follow up and the Jadad score. Our findings revealed that although cranberry had a positive effect on Helicobacter pylori eradication in adults, this effect was not statistically significant. Due to the small number of included studies and moderate heterogeneities, the potential of cranberry supplementation on Helicobacter pylori eradication should be validated in large, multicenter, and well-designed RCTs in the future.

Study Type : Meta Analysis

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.