n/a
Abstract Title:

Chemopreventive Potential of Apple Pulp Callus Against Colorectal Cancer Cell Proliferation and Tumorigenesis.

Abstract Source:

J Med Food. 2019 Jun ;22(6):614-622. Epub 2019 May 6. PMID: 31058564

Abstract Author(s):

Giulia Baldelli, Mauro De Santi, Daniele Fraternale, Giorgio Brandi, Mirco Fanelli, Giuditta Fiorella Schiavano

Article Affiliation:

Giulia Baldelli

Abstract:

This study focused on the evaluation of the chemopreventive potential of tissueculture of the"Mela Rosa Marchigiana"apple (MRM callus) that allows the amplification of secondary metabolites. The MRM pulp and MRM callus chemopreventive potential was evaluated in terms of antiproliferative activity, inhibition of tumorigenesis in soft agar cultures, cell cycle and western blotting analyses in CaCo2 and LoVo colon cancer cell lines and in JB6 promotion-sensitive (JB6 P) cells. MRM callus induced a strong concentration-dependent inhibition of colon cancer cell proliferation and suppressed 12-o-tetra-decanoyl-phorbol-13-acetate-induced tumorigenesis of JB6 Pcells in soft agar cultures. MRM callus inhibited the phosphorylation of JNK, p38, and eIF2alpha. Our data indicate that the MRM callus exerts a good antiproliferative and antitumorigenic potential through the MAP kinase inhibition and could provide natural compounds with chemopreventive properties.

Study Type : In Vitro Study
Additional Links
Substances : Apple
Pharmacological Actions : Chemopreventive : CK(5374) : AC(2086)

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.