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Article Publish Status: FREE
Abstract Title:

Capsaicin Potently BlocksInvasion of Vero Cells.

Abstract Source:

Antibiotics (Basel). 2022 May 16 ;11(5). Epub 2022 May 16. PMID: 35625310

Abstract Author(s):

Joseph A Ayariga, Daniel A Abugri, Balagopal Amrutha, Robert Villafane

Article Affiliation:

Joseph A Ayariga

Abstract:

() is one of the major food and waterborne bacteria that causes several health outbreaks in the world. Although there are few antibiotics against this bacterium, some of these drugs are challenged with resistance and toxicity. To mitigate this challenge, our group explored the ethnomedicinal/herbalism knowledge about a certain spice used in Northern Ghana in West Africa against bacterial and viral infection. This plant is(). The plant is one of the commonest food spices consumed across the world. The seed of the plant contains both capsaicin and dihydrocapsaicin. Apart from capsaicin and dihydrocapsaicin, other major capsaicinoids ininclude nordihydrocapsaicin, homodihydrocapsaicin, and homocapsaicin. In this pilot work, we investigated the antibacterial activity of pure capsaicin and capsaicin extract obtained fromagainstin vitro. Capsaicin extract showed potent inhibition ofgrowth at concentrations as low as 100 ng/mL, whereas pure capsaicin comparatively showed poorer inhibition of bacteria growth at such a concentration. Interestingly, both capsaicin extract and pure capsaicin were found to potently block ainvasion of the Vero cell in vitro. Taken together, we believed that capsaicin might work synergistically with dihydrocapsaicin or the other capsaicinoids to inhibitgrowth, whereas individually, capsaicin or dihydrocapsaicin could potently block the bacteria entry and invasion of Vero cells.

Study Type : In Vitro Study

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