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Article Publish Status: FREE
Abstract Title:

Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.

Abstract Source:

Sci Adv. 2022 Feb 25 ;8(8):eabi6110. Epub 2022 Feb 23. PMID: 35050692

Abstract Author(s):

Long Chi Nguyen, Dongbo Yang, Vlad Nicolaescu, Thomas J Best, Haley Gula, Divyasha Saxena, Jon D Gabbard, Shao-Nong Chen, Takashi Ohtsuki, John Brent Friesen, Nir Drayman, Adil Mohamed, Christopher Dann, Diane Silva, Lydia Robinson-Mailman, Andrea Valdespino, Letícia Stock, Eva Suárez, Krysten A Jones, Saara-Anne Azizi, Jennifer K Demarco, William E Severson, Charles D Anderson, James Michael Millis, Bryan C Dickinson, Savaş Tay, Scott A Oakes, Guido F Pauli, Kenneth E Palmer, , David O Meltzer, Glenn Randall, Marsha Rich Rosner

Article Affiliation:

Long Chi Nguyen

Abstract:

The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after viral entry, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD inhibits SARS-CoV-2 replication in part by up-regulating the host IRE1α RNase endoplasmic reticulum (ER) stress response and interferon signaling pathways. In matched groups of human patients from the National COVID Cohort Collaborative, CBD (100 mg/ml oral solution per medical records) had a significant negative association with positive SARS-CoV-2 tests. This studyhighlights CBD as a potential preventative agent for early-stage SARS-CoV-2 infection and merits future clinical trials. We caution against use of non-medical formulations including edibles, inhalants or topicals as a preventative or treatment therapy at the present time.

Study Type : In Vitro Study

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